RABEPRAZOLE SODIUM

RABEPRAZOLE SODIUM
PRODUCT IDENTIFICATION
CAS NO.	117976-89-3
EINECS NO.
FORMULA	C₁₈H₂₀N₃O₃S·Na
MOL WT.	381.43
H.S. CODE
TOXICITY
SYNONYMS	Aciphex;
2-[[[4-(3-methoxypropoxy) -3-methyl-2-pyridinyl]-methyl]sulfinyl] -1H–benzimidazole sodium salt;
SMILES
CLASSIFICATION	PROTON PUMP INHIBITORS /
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to yellowish crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Soluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
APPLICATIONS
Proton Pump Inhibitors (PPIs) are a group of drugs to reduce the production of acid by blocking the enzyme (hydrogen-potassium adenosine triphosphatase) in parietal cells that produces acid. They are used in the treatment of ulcers caused by taking nonsteroidal anti-inflammatory drugs, Zollinger-Ellison syndrome, and symptomatic gastroesophageal reflux disease. They are also used in eradicating Helicobacter pylori, in combination with antibiotics (e.g. amoxycillin, clarithromycin or metronidazole in case of penicillin-hypersensitive patients). Another lowering-acid medicines are H2 antagonist drugs which reduce the production of acid by blocking the H2 subtype of histamine receptors. Commecially available PPIs include; Omeprazole (CAS RN: 73590-58-6) Lansoprazole (CAS RN: 103577-45-3) Esomeprazole (CAS RN: 161796-78-7) Pantoprazole (CAS RN: 102625-70-7) Rabeprazole (CAS RN: 117976-89-3) Rabeprazole, a substituted benzimidazole, inhibits gastric acid secretion. The sodium salt of rabeprazole is a white to yellowish crystalline powder; soluble in water; slightly soluble in soluble in water and methanol; freely soluble in ethanol; unstable in air; administered orally. It is a weak base; unstable under acid conditions, but stable in alkaline media. The chemical designation is 2-[[[4-(3-methoxypropoxy) -3-methyl-2-pyridinyl]-methyl] sulfinyl] -1H–benzimidazole sodium salt.
SALES SPECIFICATION
APPEARANCE	white to yellowish crystalline powder
IDENTIFICATION	Complies Test A,B
ASSAY (HPLC)	98.5 - 101.5%
INDIVIDUAL IMPURITY	0.5% max
HEAVY METALS	20ppm max
LOSS ON DRYING	0.1% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
OTHER INFORMATION
`Hazard Symbols: XN, Risk Phrases:` 20/21/22,`Safety Phrases:`36
PRICES